Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.
Benoît Delignat‐Lavaud, Jana Kano, Charles Ducrot, Ian Omer Massé, Sriparna Mukherjee, Nicolas Giguère, Luc Moquin, Catherine Lévesque, Samuel Burke, Raphaëlle Denis, Marie-Josée Bourque, Alex Tchung, Pedro Rosa‐Neto, Daniel Lévesque, Louis De Beaumont, Louis‐Éric Trudeau
This study shows that phasic dopamine release in mice is not essential for basic motor behaviors, as motor functions remain intact despite near-complete loss of activity-dependent dopamine release.
Nature Communications · Jul 11, 2023Peer-reviewedNeuroscience