Louis‐Éric Trudeau

This study shows that repeated exposure to viral and bacterial danger signals in Parkin-deficient mice induces inflammation but does not cause dopaminergic denervation or motor dysfunction.

This study shows that PINK1 in myeloid cells represses mtDNA release and immune signaling, which contributes to neuronal pathology in Parkinson's disease models.

This study shows that loss of neurexins in dopamine neurons disrupts inhibitory synapse formation and reduces neuronal survival in culture.

This study identifies early immune dysregulation in PINK1 KO mice following intestinal infection, showing myeloid cell activation and T cell response as key factors in PD-like disease progression.

This study shows that a single Citrobacter rodentium infection increases blood-brain barrier permeability and triggers neuroinflammation in Pink1 knockout mice without dopamine neuron loss.

This study characterizes dopaminergic neurons in the gut using a DAT-cre reporter mouse line, revealing distinct subtypes with dual-transmitter content.

This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.

A mouse model with patient-derived DAT mutations reveals dopaminergic dysfunction linked to parkinsonism and psychiatric symptoms through behavioral and neurochemical changes.

This study shows that phasic dopamine release in mice is not essential for basic motor behaviors, as motor functions remain intact despite near-complete loss of activity-dependent dopamine release.

This study shows that amphetamine exposure in adolescence causes sex-specific changes in dopamine axon growth via Netrin-1/DCC signaling, with male mice showing increased vulnerability.

This study shows that neurexins regulate dopamine neuron connectivity and neurotransmission by affecting dopamine reuptake and GABA co-release.

This paper shows that neonatal 6-OHDA lesions of the SNc in mice lead to compensatory axonal sprouting from surviving SNc dopaminergic neurons, without contribution from VTA neurons.

This study shows dopaminergic neurons form a unique axonal arbor with mostly non-synaptic terminals, expressing exocytosis proteins and being active, and highlights the role of specific proteins in synapse formation.

The paper investigates somatodendritic dopamine release in mice, showing that synaptotagmin 4 and 7 are required for this process, while axonal release remains unaffected.

This study investigates the role of Vglut2 in dopamine neuron plasticity and post-lesional striatal reinnervation, finding that Vglut2 expression can be reactivated in adult neurons to support axonal recovery.

This study shows that D-amphetamine reduces addiction-like behaviors and DAT sensitization in rats during intermittent cocaine self-administration.