Nicolas Giguère

This study shows that repeated exposure to viral and bacterial danger signals in Parkin-deficient mice induces inflammation but does not cause dopaminergic denervation or motor dysfunction.

This study shows that a single Citrobacter rodentium infection increases blood-brain barrier permeability and triggers neuroinflammation in Pink1 knockout mice without dopamine neuron loss.

This study shows that mitochondrial antigen-specific CD8+ T cells can induce nigrostriatal dysfunction and dopamine neuron degeneration in mice, supporting an immune-driven mechanism in Parkinson's disease.

This study shows that phasic dopamine release in mice is not essential for basic motor behaviors, as motor functions remain intact despite near-complete loss of activity-dependent dopamine release.

This study shows that neurexins regulate dopamine neuron connectivity and neurotransmission by affecting dopamine reuptake and GABA co-release.

This paper shows that neonatal 6-OHDA lesions of the SNc in mice lead to compensatory axonal sprouting from surviving SNc dopaminergic neurons, without contribution from VTA neurons.