Cancer BiologybioRxivPreprint
Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4
Gilson J. Sanchez, Zeyu Liu, Samuel Hunter…·Xuedong Liu
This study shows largazole suppresses superenhancer accessibility by inhibiting SP1 and BRD4, leading to mitotic chromosome misalignment and cell cycle arrest.