Jessica Westfall

Histone Deacetylase Inhibitor Largazole Deactivates A Subset of Superenchancers and Causes Mitotic Chromosome Mis-alignment by Suppressing SP1 and BRD4

This study shows largazole suppresses superenhancer accessibility by inhibiting SP1 and BRD4, leading to mitotic chromosome misalignment and cell cycle arrest.

Characterizing Primary transcriptional responses to short term heat shock in paired fraternal lymphoblastoid lines with and without Down syndrome.

The paper investigates the heat shock response in lymphoblastoid cell lines with and without trisomy 21, finding a more robust response in trisomy 21 cells.

Transcription factor enrichment analysis (TFEA): Quantifying the activity of hundreds of transcription factors from a single experiment

TFEA quantifies transcription factor activity changes from perturbation data, identifying key regulators and temporal regulatory networks.

Applying knowledge-driven mechanistic inference totoxicogenomics

The paper introduces MechSpy, a framework that generates mechanistic hypotheses of toxicity by combining gene expression data with biological knowledge, and validates predictions experimentally.