Amphisome biogenesis couples synaptic autophagy to local protein synthesis
Maria Andres‐Alonso, Catrin Schweizer, Carolina Montenegro‐Venegas, Sarah Wirth, Carola Schneider, Rabia Turacak, Katarzyna M. Grochowska, Rabia Bice Aydin, Lisa Mahnke, Shuting Yin, Anna Karpova, Rudolph Reimer, Antonio Virgilio Failla, Tobias M. Boeckers, Eckart Dieter Gundelfinger, Michael R. Kreutz
The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.
bioRxiv · Sep 23, 2025 · PreprintNeuroscience