Anna Karpova

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

This study shows that axonal amphisome trafficking in locus coeruleus neurons is regulated by norepinephrine signaling and neuronal activity, with implications for proteostasis.

The paper shows that Nitarsone prevents Aβ-induced CREB inactivation and synaptic loss in AD models by blocking Jacob-mediated signalosome assembly.

This study shows that nsmf gene knockout does not protect against hypoxia and NMDA-induced neuronal death, suggesting JaCS is mainly relevant in chronic extrasynaptic NMDAR activation.

This study shows that synaptic activity controls DNA methylation by degrading DNMT3a1 via NMDAR-dependent neddylation.

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.