Eckart Dieter Gundelfinger

This study investigates the effects of Bassoon gene ablation in specific mouse neuron populations on behavioral and structural phenotypes resembling schizophrenia.

This study shows that bassoon is essential for adult ocular dominance plasticity but not juvenile plasticity, involving presynaptic changes in synapsin phosphorylation.

This study shows that conditional ablation of the Bassoon gene in GABAergic interneurons leads to autism-like behaviors and synaptic dysfunction in mice.

This study investigates the role of Bassoon in different synapse types by generating conditional knockout mice, finding distinct effects on brain activity and learning.

The paper shows that amphisomes formed at presynaptic boutons during sustained synaptic activity facilitate protein degradation and local replenishment through mRNA translation.

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

The paper establishes a mouse line for cell-type specific proteomic labeling and identifies regional astrocyte proteome differences using mass spectrometry.

This study identifies bassoon's role in regulating synaptic vesicle pools through presynaptic phosphorylation and cAMP homeostasis, revealing its impact on neurotransmitter release.

This study shows SIPA1L2 connects TrkB-containing amphisomes to dynein for retrograde trafficking and local signaling at presynaptic terminals, essential for BDNF-dependent plasticity.

This study shows dopamine modulates ECM integrity at excitatory synapses via D1 receptors and proteases ADAMTS-4/5, affecting brevican and aggrecan cleavage.