Aneuploidy-induced proteostasis disruption impairsmitochondrial functions and mediates aggregation ofmitochondrial precursor proteins through SQSTM1/p62
Prince Saforo Amponsah, Jan-Eric Boekenkamp, Olha Kurpa, Svenja Lenhard, Anna Myronova, Daniel Osmar Vega Velazquez, Celina Hirschelmann, Christian Behrends, Johannes M. Herrmann, Markus Räschle, Zuzana Štorchová
This study shows that aneuploidy disrupts proteostasis, leading to mitochondrial dysfunction and accumulation of mitochondrial precursor proteins in cytosolic p62 bodies.
Nature Communications · Jun 17, 2025Peer-reviewedCell Biology