A recombinant expression system for the Plasmodium falciparum proteasome enables structural analysis of its assembly and the design of selective inhibitors
Pavla Fajtová, Hanxiao Zhang, Liam Urich, Elany Barbosa da Silva, Cesar Hoffmann da Silva, Jehad Almaliti, Momen Al-Hindy, Evžen Bouřa, Laura A. Kirkman, Gang Lin, Matthew S. Bogyo, David A. Fidock, William H. Gerwick, Jianhua Zhao, Anthony John O’Donoghue
This paper develops a recombinant Pf20S platform for structural analysis and inhibitor design, identifying a selective inhibitor with high potency against Plasmodium falciparum proteasome.
bioRxiv · Aug 13, 2025 · PreprintBiochemistry