Pavla Fajtová

Carbohydrate-active enzymes of giant viruses: Molecular and biochemical characterization of glycosyl hydrolases from algae-infecting chloroviruses

This study characterizes glycosyl hydrolase 18 chitinases from chloroviruses, revealing their enzymatic properties, structural features, and potential as biotechnological tools for algal control.

A recombinant expression system for the Plasmodium falciparum proteasome enables structural analysis of its assembly and the design of selective inhibitors

This paper develops a recombinant Pf20S platform for structural analysis and inhibitor design, identifying a selective inhibitor with high potency against Plasmodium falciparum proteasome.

Structural insights into Salinosporamide A mediated inhibition of the human 20S proteasome

The paper presents the cryo-EM structure of the human 20S proteasome bound to marizomib, revealing its binding mode and irreversible inhibitory mechanism.

Native Metabolomics Identifies the Rivulariapeptolide Family of Protease Inhibitors

This study uses native metabolomics to identify a family of protease inhibitors from cyanobacteria, revealing their structure and potent biological activity.