Jianhua Zhao

The paper identifies an uncompetitive allosteric inhibitor of mitochondrial creatine kinase that stabilizes loop closure, preventing creatine binding and phosphocreatine release.

This paper develops a recombinant Pf20S platform for structural analysis and inhibitor design, identifying a selective inhibitor with high potency against Plasmodium falciparum proteasome.

This paper identifies how PVT1 rearrangements in MYC+ cancers generate oncogenic peptides that synergistically activate MYC, AKT, and RAS-MAPK pathways, enhancing tumor aggressiveness.

This study reveals the structural steps of human 20S proteasome assembly using cryo-EM, showing how chaperones facilitate intermediate stages and trigger final maturation.

The paper investigates the structural and mechanistic features of mitochondrial creatine kinase (uMtCK) and evaluates the efficacy of a covalent inhibitor in breast cancer cells.

The paper describes a method combining CRISPR/Cas and fluorescence cell sorting to efficiently tag and purify endogenous human proteins for structural analysis using cryo-EM.