NeuroscienceNature CommunicationsPeer-reviewed
Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy
Annie Lee, Chandana Kondapalli, Daniel M. Virga…·Franck Polleux
This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.