Franck Polleux

This study shows that SRGAP2 limits experience-dependent structural synaptic plasticity in adult cortical circuits, with its deletion increasing plasticity in mice and suggesting a role for human-specific paralogs in human neurons.

The paper shows that clustered excitatory synapses on dendrites improve place field encoding efficiency in hippocampal neurons compared to randomized distributions.

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.

RESPAN improves dendritic spine quantification by integrating deep learning for restoration, segmentation, and analysis, achieving higher accuracy and usability than existing methods.

This study shows that distal tuft dendrites in hippocampal neurons do not initiate place field formation but instead shape place fields through variable recruitment and local activity.

The paper shows that most axonal mitochondria in mammalian neurons lack mtDNA and do not produce ATP, contrasting with dendritic mitochondria.

The paper experimentally tests a model of synaptic plasticity in awake mice, showing asymmetric potentiation and depression of synaptic inputs around plateau spikes and compartment-specific differences in plasticity.

The paper shows that human-specific genes SRGAP2B/C regulate synaptic neoteny in human cortical neurons by modulating SYNGAP1 levels.

This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.

This study shows that the human-specific gene SRGAP2C increases cortico-cortical connectivity and improves sensory processing and behavioral performance in mice.

The paper investigates the role of intracellular Ca2+ release in shaping dendritic feature selectivity in hippocampal neurons during spatial navigation.

The paper presents a semi-automated reconstruction of mouse primary visual cortex from electron microscopy data, revealing structural and functional relationships in cortical circuits.

The paper shows that Arhgap11a mRNA localization and local translation in radial glial cells control cortical development by regulating RGC morphology and neuron positioning.

This study investigates how human-specific paralogs SRGAP2B and SRGAP2C modulate SRGAP2A-dependent synaptic development in human cortical neurons.

This study identifies Robo2 as a synaptogenic molecule critical for excitatory synapse formation and spatial coding in hippocampal circuits.

This study shows that haploinsufficiency of the autism candidate gene Nuak1 in mice causes cortical development defects and behavioral abnormalities resembling ASD, intellectual disability, and schizophrenia.

The paper introduces CoLSSEM, a method combining fluorescent labeling and electron microscopy to visualize synaptic connections in single neurons in vivo.

The paper maps excitatory and inhibitory synapses across dendritic trees of cortical neurons and finds local balance in their ratio despite domain-specific density variations.

The paper identifies hominin-specific NOTCH2 paralogs that enhance human cortical neurogenesis by modulating Delta/Notch interactions.