Author

Daniel M. Virga

Columbia UniversityORCID 0000-0002-7248-3596Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Annie LeeiD· 2 shared Franck PolleuxiD· 2 shared Tommy L. LewisiD· 2 shared Abigail Morgan· 1 shared Andrew A. SprouliD· 1 shared Archana AshokiD· 1 shared Aubrianna DeckeriD· 1 shared Badri Narayan VardarajaniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersNeuroscience

Annie LeeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer's Disease Susceptibility

Nicole Vo, Cory D. Rillahan, Zena K. Chatila, Daniel M. Virga, Jennifer L. Hall, Kirstin A. Tamucci, Mamunur Rashid, Sarah M. Connor, Sana Chintamen, Gaelen Guzman, Mariko F. Taga, Minghua Liu, Philip L. De Jager, Peter St George‐Hyslop, Annie Lee, , Elizabeth M. Bradshaw

This study identifies CD45 as a sialic acid-dependent binding partner of CD33, showing that their interaction contributes to Alzheimer's disease susceptibility through impaired microglial function.

bioRxiv · Jul 28, 2025 · PreprintNeuroscience

The majority of axonal mitochondria in mammalian neuronslack mitochondrial DNA and do not produce ATP

Yusuke Hirabayashi, Tommy L. Lewis, Yudan Du, Emiliano Zamponi, Parker Kneis, Jennifer U Jones, Aubrianna Decker, Giovanna Coceano, Jonatan Alvelid, Momone Kikuchi, Masafumi Tsuboi, Shogo Suga, Koyo Shibayama, Maëla A. Paul, Daniel M. Virga, , Franck Polleux

The paper shows that most axonal mitochondria in mammalian neurons lack mtDNA and do not produce ATP, contrasting with dendritic mitochondria.

bioRxiv · Feb 12, 2024 · PreprintNeuroscience

Aβ42 oligomers trigger synaptic loss through CAMKK2-AMPK-dependent effectors coordinating mitochondrial fission and mitophagy

Annie Lee, Chandana Kondapalli, Daniel M. Virga, Tommy L. Lewis, So Yeon Koo, Archana Ashok, Georges Mairet‐Coello, Sébastien Herzig, Marc Foretz, Benoı̂t Viollet, Reuben J. Shaw, Andrew A. Sproul, Franck Polleux

This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.

Nature Communications · Aug 1, 2022Peer-reviewedNeuroscience