Author
UCB Pharma (Belgium)
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
4 papers
Recent·Most cited
Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Niran Maharjan…·Hilal Ahmed Lashuel
This study investigates how C-terminal truncations of alpha-synuclein (aSyn) affect Lewy body (LB) formation and pathology in Parkinson's disease by analyzing their role in fibril processing and aggregation.
Annie Lee, Chandana Kondapalli, Daniel M. Virga…·Franck Polleux
This study shows Aβ42 oligomers cause synaptic loss by activating CAMKK2-AMPK, which coordinates mitochondrial fission and mitophagy in neurons.
Anne‐Laure Mahul‐Mellier, Melek Firat Altay, Johannes Burtscher…·Hilal Ahmed Lashuel
Calpain-1/2 cleavage of the alpha-synuclein C-terminus after fibril formation is reported to drive seeding, aggregation and the maturation of Lewy-body-like inclusions in primary neurons.
Prashant Kumar Srivastava, Jonathan M. van Eyll, Patrice Godard…·Michael R. Johnson
This paper introduces CRAFT, a computational framework for drug target identification, and validates Csf1R as a novel anti-epileptic target using pre-clinical models.