Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells
Jing Guo, Luyao Gong, Haiying Yu, Ming Li, Qiaohui An, Zhenquan Liu, Shuru Fan, Changjialian Yang, Dahe Zhao, Jing Han, Hua Xiang
This paper develops a compact type I-F2 CRISPR-Cas system for transcriptional activation and base editing in human cells, achieving a wide editing window and high efficiency.
Nature Communications · Aug 23, 2024Peer-reviewedMolecular Biology