Jing Guo

HESTIA: Scalable Multimodal Integration of Histology and High-Resolution Spatial Transcriptomics for Robust Spatial Domain Identification

HESTIA integrates histology and spatial transcriptomics to identify spatial domains in large-scale data, improving clustering accuracy and mapping tumor heterogeneity.

A Cross-Species Systems Genetics Framework Identifies Causal Genes in Diabetic Nephropathy

This paper identifies causal genes in diabetic nephropathy using a cross-species systems genetics framework, finding 192 candidate genes with 40% validated in humans.

CSRefiner: A lightweight framework for fine-tuning cell segmentation models with small datasets

CSRefiner improves cell segmentation accuracy with small datasets by fine-tuning existing models for spatial transcriptomics.

CellBin:a generalist framework to process spatial omics data to cell level

CellBin processes spatial omics data to create cell-level matrices, outperforming existing methods across multiple platforms and omics types.

Engineered minimal type I CRISPR-Cas system for transcriptional activation and base editing in human cells

This paper develops a compact type I-F2 CRISPR-Cas system for transcriptional activation and base editing in human cells, achieving a wide editing window and high efficiency.

CellBin: a highly accurate single-cell gene expression processing pipeline for high-resolution spatial transcriptomics

CellBin processes high-resolution spatial transcriptomics data to generate accurate single-cell gene expression profiles, improving accuracy and efficiency in mouse brain tissue analysis.

Spatial-ID: a cell typing method for spatially resolved transcriptomics via transfer learning and spatial embedding

Spatial-ID improves cell type annotation in spatial transcriptomics by combining transfer learning and spatial embedding, outperforming existing methods on public datasets.

Verified the effectiveness of AsCpf1 system in a variety of vertebrate species

The paper shows that AsCpf1 activity varies across vertebrate species due to temperature differences, as demonstrated by in vitro experiments.