The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death
Gabrielle Lê-Bury, Chantal Deschamps, Floriane Herit, Alexander V. Predeus, Audrey Dumas, Melita A. Gordon, Jay C. D. Hinton, Petr Brož, Florence Niedergang
This study identifies that the unique lipopolysaccharide (LPS) of Salmonella Typhimurium ST313 reduces pyroptosis and inflammasome activation in human macrophages, contributing to its pathogenicity.
bioRxiv · Sep 29, 2025 · PreprintMicrobiology