Jay C. D. Hinton

The paper compares the intracellular replication of different Salmonella pathovariants in human macrophages, finding that bloodstream-associated variants replicate more efficiently than global epidemic isolates.

This study identifies the molecular mechanisms of Eut BMC assembly in Salmonella, revealing a 'Shell-first' pathway and the role of EutQ in cargo encapsulation and BMC formation.

This study identifies that the unique lipopolysaccharide (LPS) of Salmonella Typhimurium ST313 reduces pyroptosis and inflammasome activation in human macrophages, contributing to its pathogenicity.

The paper characterizes two Salmonella Typhimurium strains for a first-in-human challenge model, confirming their genomic and phenotypic stability post-manufacture.

This study identifies that Salmonella effector kinase SteC is activated by host-mediated phosphorylation at S379, which enhances its kinase activity and promotes actin polymerisation.

The paper characterizes the BREX system in Salmonella, determines the structure of PglX, and shows how rational engineering expands phage targeting and host motif methylation.

This study identifies CirA as a colicin receptor that enhances resistance to ColIb in S. Typhimurium despite lacking the immunity protein.

This paper identifies a novel SPI-2 effector, SseM, in Salmonella that interacts with the dystrophin-associated protein complex and modulates bacterial growth in mice.

This study analyzes 836 Salmonella Panama genomes to reveal population structure, antimicrobial resistance, and genetic markers of invasiveness across global regions.

The paper identifies a new sublineage of Salmonella Typhimurium ST313 in Malawi with a gene expression signature and increased fitness compared to its parent lineage.

The paper develops a real-time PCR assay to differentiate Salmonella Enteritidis clades for public health surveillance in resource-limited settings.

The paper analyzes genomic and phylogenetic data of Salmonella Typhimurium and monophasic variants from Colombia to understand their population structure, evolution, and antibiotic resistance.

The paper identifies a non-coding SNP in the pgtE promoter of Salmonella ST313 that increases PgtE expression, contributing to serum resistance and virulence in a chicken model.