Melita A. Gordon

The unique lipopolysaccharide composition of Salmonella Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell death

This study identifies that the unique lipopolysaccharide (LPS) of Salmonella Typhimurium ST313 reduces pyroptosis and inflammasome activation in human macrophages, contributing to its pathogenicity.

Comparative phenotypic, genomic and transcriptomic characterisation of two Salmonella Typhimurium strains for a first-in-human challenge model

The paper characterizes two Salmonella Typhimurium strains for a first-in-human challenge model, confirming their genomic and phenotypic stability post-manufacture.

Salmonella enterica serovar Typhimurium ST313 sublineage 2.2 has emerged in Malawi with a characteristic gene expression signature and a fitness advantage

The paper identifies a new sublineage of Salmonella Typhimurium ST313 in Malawi with a gene expression signature and increased fitness compared to its parent lineage.

Direct inference and control of genetic population structure from RNA sequencing data

This paper introduces RGStraP, a tool to infer genetic population structure from RNAseq data and shows it can control for population structure in gene expression analyses.

The role of a single non-coding nucleotide in the evolution of an epidemic African clade of Salmonella

The paper identifies a non-coding SNP in the pgtE promoter of Salmonella ST313 that increases PgtE expression, contributing to serum resistance and virulence in a chicken model.