Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release
Anuj Kumar, Emmanuel Combe, Elena M. Smekalova, Selam Dejene, Dominique Leboeuf, Chao-Ying Chen, Léa Mougené, Marine Deleume, Caroline Scholtès, Marie‐Laure Plissonnier, Xavier Grand, María Guadalupe Martínez, Giuseppe Ciaramella, Francine M. Gregoire, Michael S. Packer, , Fabien Zoulim
This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.
bioRxiv · Feb 6, 2026 · PreprintMolecular Biology