Author

María Guadalupe Martínez

Centre National de la Recherche ScientifiqueORCID 0000-0002-7236-2911Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Barbara TestoniiD· 3 shared Caroline ScholtèsiD· 2 shared Chloé GoldsmithiD· 2 shared Fabien ZoulimiD· 2 shared Héctor Hernández‐VargasiD· 2 shared Isabelle CheminiD· 2 shared Xavier GrandiD· 2 shared Anaëlle Dubois· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Barbara TestoniORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

Anuj Kumar, Emmanuel Combe, Elena M. Smekalova, Selam Dejene, Dominique Leboeuf, Chao-Ying Chen, Léa Mougené, Marine Deleume, Caroline Scholtès, Marie‐Laure Plissonnier, Xavier Grand, María Guadalupe Martínez, Giuseppe Ciaramella, Francine M. Gregoire, Michael S. Packer, , Fabien Zoulim

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

bioRxiv · Feb 6, 2026 · PreprintMolecular Biology

Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes

Fleur Chapus, Guillaume Giraud, Pélagie Huchon, Caroline Charre, Chloé Goldsmith, Mélanie Rodà, María Guadalupe Martínez, Judith Fresquet, Audrey Diederichs, Maëlle Locatelli, Hélène Polvèche, Xavier Grand, Caroline Scholtès, Isabelle Chemin, Héctor Hernández‐Vargas, , Barbara Testoni

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

bioRxiv · Jan 17, 2024 · PreprintMolecular Biology

Epigenetic heterogeneity after de novo assembly of native full-length Hepatitis B Virus genomes

Chloé Goldsmith, Damien Cohen, Anaëlle Dubois, María Guadalupe Martínez, Kilian Petitjean, Anne Corlu, Barbara Testoni, Héctor Hernández‐Vargas, Isabelle Chemin

The paper develops a method to detect 5mCpG in HBV genomes without bisulfite conversion, enabling de novo assembly and identification of epigenetic clusters in infected patients.

bioRxiv · May 29, 2020 · PreprintGenomics