Xavier Grand

This study evaluates precision-cut liver slices as an ex vivo model for studying HBV/HDV co-infection and testing antiviral agents.

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

This study shows DDX5 and DDX17 regulate HBV RNA splicing, affecting viral protein expression and liver disease progression.

Bolero is a computational workflow for analyzing HBV long-read sequencing data to quantify viral RNA transcripts and spliced variants, enabling study of cccDNA transcriptional activity.

This study shows that MYCN and helicases DDX17/DDX5 have opposing roles in transcription termination and chimeric transcript production in neuroblastoma, with MYCN inhibiting helicase activity and promoting harmful RNA molecules.

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

The paper identifies de novo monoallelic DDX17 variants in 11 patients with neurodevelopmental disorders and shows DDX17 dysfunction causes neuronal migration and axon outgrowth defects in multiple models.