Author

Fabien Zoulim

Lyon 1 UniversitéORCID 0000-0002-2245-0083Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3 Bioinformatics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1

Frequent Co-Authors

Barbara TestoniiD· 5 shared Xavier GrandiD· 5 shared Audrey Diederichs· 3 shared Cyril F. BourgeoisiD· 3 shared Guillaume GiraudiD· 3 shared Michel L. RivoireiD· 3 shared Armando Andres Roca SuareziD· 2 shared Caroline ScholtèsiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersMolecular Biology

Barbara TestoniORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Precision-cut liver slices as a model for evaluating therapeutic agents against hepatitis B and delta viruses

Armando Andres Roca Suarez, Maud Michelet, Marie‐Laure Plissonnier, Anaëlle Dubois, Audrey Diederichs, Sarah Heintz, Maria Sàez‐Palma, Mathieu Ben Abu, Xavier Grand, Anaïs Favre, Alain Chédotal, Nicolaas Van Renne, Simon P. Fletcher, François Mithieux, Pierre Emmanuel Bonnot, , Barbara Testoni

This study evaluates precision-cut liver slices as an ex vivo model for studying HBV/HDV co-infection and testing antiviral agents.

bioRxiv · Aug 29, 2026 · PreprintMicrobiology

Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

Anuj Kumar, Emmanuel Combe, Elena M. Smekalova, Selam Dejene, Dominique Leboeuf, Chao-Ying Chen, Léa Mougené, Marine Deleume, Caroline Scholtès, Marie‐Laure Plissonnier, Xavier Grand, María Guadalupe Martínez, Giuseppe Ciaramella, Francine M. Gregoire, Michael S. Packer, , Fabien Zoulim

This study uses adenine base editing to target HBV DNA and suppress HBsAg production and HDV release in vitro and in vivo.

bioRxiv · Feb 6, 2026 · PreprintMolecular Biology

DDX5 and DDX17 RNA helicases regulate hepatitis B virus RNA splicing

Guillaume Giraud, Xavier Grand, Pélagie Huchon, Mélanie Rodà, Audrey Diederichs, Fleur Chapus, Francesca De Nicola, Romain Parent, Michel L. Rivoire, Cyril F. Bourgeois, Fabien Zoulim, Barbara Testoni

This study shows DDX5 and DDX17 regulate HBV RNA splicing, affecting viral protein expression and liver disease progression.

bioRxiv · Feb 14, 2025 · PreprintMolecular Biology

Bolero: a dedicated workflow to decipher Hepatitis B virus transcriptome from long-reads sequencing method coupled to 5RACE amplification of transcripts

Xavier Grand, Guillaume Giraud, Alia Rifki, Alexia Paturel, Delphine Bousquet, Armando Andres Roca Suarez, Cyril F. Bourgeois, Massimo Levrero, Fabien Zoulim, Barbara Testoni

Bolero is a computational workflow for analyzing HBV long-read sequencing data to quantify viral RNA transcripts and spliced variants, enabling study of cccDNA transcriptional activity.

bioRxiv · Sep 17, 2024 · PreprintBioinformatics

Helicases DDX5 and DDX17 promote Hepatitis B Virus transcription termination heterogeneity in infected human hepatocytes

Fleur Chapus, Guillaume Giraud, Pélagie Huchon, Caroline Charre, Chloé Goldsmith, Mélanie Rodà, María Guadalupe Martínez, Judith Fresquet, Audrey Diederichs, Maëlle Locatelli, Hélène Polvèche, Xavier Grand, Caroline Scholtès, Isabelle Chemin, Héctor Hernández‐Vargas, , Barbara Testoni

The paper identifies DDX5 and DDX17 as factors promoting HBV transcriptional readthrough and affecting viral RNA stability and replication.

bioRxiv · Jan 17, 2024 · PreprintMolecular Biology