Author

Chara Mastrokalou

Cancer Research Horizons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Curtis HartiD· 2 shared David WalteriD· 2 shared Douglas Ross‐ThrieplandiD· 2 shared Khalid SaeediD· 2 shared Nikhil GuptaiD· 2 shared Adam SpruceiD· 1 shared Alex Kalinka· 1 shared Andy SayeriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Curtis HartORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Comparative Single-Cell Profiling of CRISPR Knockout and Interference Defines Modality-Specific Strengths in Functional Genomics

Nikhil Gupta, Andy Sayer, Malwina Prater, Chara Mastrokalou, Khalid Saeed, Curtis Hart, Ricardo J. Miragaia, Ashutosh Trehan, Ultan McDermott, Magdalena E Strauß, Douglas Ross‐Thriepland, David Walter, Alex Kalinka

This study compares CRISPR knockout and interference methods using single-cell RNA sequencing to evaluate their strengths in functional genomics.

bioRxiv · Aug 27, 2026 · PreprintGenomics

Scarless conditional sgRNAs via endogenous mascRNA processing enable rapid and temporally controlled genome editing

Curtis Hart, Lovely Jael Paul Solomon Devakumar, Khalid Saeed, Adam Spruce, Chara Mastrokalou, Sebastian Łukasiak, Douglas Ross‐Thriepland, David Walter, Nikhil Gupta

The paper develops a scarless conditional sgRNA system using endogenous RNA processing to enable precise temporal control of genome editing with improved efficiency and fidelity.

bioRxiv · Aug 22, 2026 · PreprintCell Biology