Author

Douglas Ross‐Thriepland

AstraZeneca (United Kingdom)ORCID 0000-0001-6226-2223Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cell Biology· 1 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 2 Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

David WalteriD· 3 shared Khalid SaeediD· 3 shared Nikhil GuptaiD· 3 shared Chara Mastrokalou· 2 shared Curtis HartiD· 2 shared Sebastian Łukasiak· 2 shared Ultan McDermottiD· 2 shared Adam SpruceiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

David WalterORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

GenomicsbioRxivPreprintAug 27, 2026

Comparative Single-Cell Profiling of CRISPR Knockout and Interference Defines Modality-Specific Strengths in Functional Genomics

Nikhil Gupta, Andy Sayer, Malwina Prater…·Alex Kalinka

This study compares CRISPR knockout and interference methods using single-cell RNA sequencing to evaluate their strengths in functional genomics.

DOI 10.64898/2026.08.26.747303

scRNA-seqexperimental assay

𝕏 PostBluesky

Cell BiologybioRxivPreprintAug 22, 2026

Scarless conditional sgRNAs via endogenous mascRNA processing enable rapid and temporally controlled genome editing

Curtis Hart, Lovely Jael Paul Solomon Devakumar, Khalid Saeed…·Nikhil Gupta

The paper develops a scarless conditional sgRNA system using endogenous RNA processing to enable precise temporal control of genome editing with improved efficiency and fidelity.

DOI 10.64898/2026.08.20.745814

genetic perturbation / CRISPRgene regulatory network inference

𝕏 PostBluesky

Molecular BiologyBMC GenomicsPeer-reviewedFeb 26, 2025

A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency

Sebastian Łukasiak, Alex T. Kalinka, Nikhil Gupta…·David Walter

The paper benchmarks CRISPR sgRNA design algorithms and creates smaller, efficient libraries for loss-of-function screens.

12 citations

humanCRISPR screen

𝕏 PostBluesky