Charis‐Patricia Segeritz

This study develops bioengineered human skeletal muscle tissues that mature metabolically and functionally, capturing key aspects of glucose metabolism and response to exercise and pharmacological agents.

This study shows that both terminal misfolding and polymerisation of Z 1-antitrypsin contribute to liver disease phenotypes, with terminal misfolding driving pro-fibrotic responses and metabolic changes.

This study generates functional hepatocytes from human pluripotent stem cells using forward programming with nuclear receptors, bypassing the limitations of traditional differentiation methods.