Jonas R. Knudsen

Decreased food intake contributes to elevated insulin-responsiveness in pre-clinical cancer cachexia

This study shows that reduced food intake in cancer cachexia increases skeletal muscle insulin responsiveness through AKT signaling, independent of tumor presence.

Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism

This study develops bioengineered human skeletal muscle tissues that mature metabolically and functionally, capturing key aspects of glucose metabolism and response to exercise and pharmacological agents.

Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

The Rho GTPase Rac1 mediates exercise training adaptations

This study identifies Rac1 as a key regulator of exercise training adaptations by showing its role in protein synthesis, glycogen resynthesis, and running capacity in mice and human muscle.

AMPK is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice

This study shows that AMPK is upregulated in human cachectic muscle and that AMPK deficiency in mice worsens cancer-induced metabolic dysfunction and cachexia.