Charity W Law

This paper introduces an RNA-seq mixture experiment using two cancer cell lines to benchmark library preparation kits and analysis methods, finding that total RNA kits and voom with quality weights perform best.

The paper evaluates methods for detecting differential transcript usage from RNA-seq data, showing that isoform-level pre-filtering improves false discovery rate control.

This paper reviews statistical methods for detecting differentially methylated loci and regions, focusing on challenges like experimental design, false discovery control, and batch effects.