A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans
Jianfeng Lin, Jian Miao, Katherine G. Schaefer, Charles M. Russell, Robert J. Pyron, Fuming Zhang, Quynh T. Phan, Norma V. Solis, Hong Liu, Masato Tashiro, Jonathan S. Dordick, Robert J. Linhardt, Michael R. Yeaman, Gavin M. King, Francisco N. Barrera, , Scott G. Filler
This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.
Nature Microbiology · Sep 16, 2024Peer-reviewedMicrobiology