Jianfeng Lin

This study shows that HosA, a histone deacetylase in A. fumigatus, regulates stress resistance, host cell interactions, and virulence by modulating gene expression related to secondary metabolism and energy metabolism.

This paper shows EGFR signaling is essential for host defense against invasive aspergillosis, as its inhibition worsens infection outcomes in immunosuppressed mice.

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

This paper develops DEC-AmB-LLs, Dectin-1-coated antifungal liposomes, which significantly enhance the effectiveness of amphotericin B against fungal pathogens.