Francisco N. Barrera

Cholesterol promotes the formation of dimers and oligomers of the receptor tyrosine kinase ROR1

This study shows that cholesterol promotes ROR1 dimerization and oligomerization in human cells, independent of ligand binding.

Bayesian analysis and efficient algorithms for single-molecule fluorescence data and step counting

This paper introduces a Bayesian nonparametric framework for analyzing single-molecule fluorescence data, demonstrating its effectiveness through synthetic and experimental data.

CAR T cell cytotoxic responses are rapidly generated and sensitive to the unligated TCR

This study investigates CAR T cell cytotoxic responses, showing they are sensitive to TCR interactions and can be modulated by inhibitory peptides.

Cholesterol inhibits oncogenic EphA2 activation

This study shows that cholesterol inhibits EphA2 self-assembly and oncogenic signaling by preventing its activation through an in-trans mechanism involving protein kinase A.

Tumor-targeted hydroxyapatite nanoparticles for dual-mode diagnostic imaging and near-infrared light-triggered photothermal cancer therapy

This paper develops tumor-targeted hydroxyapatite nanoparticles for dual-mode imaging and photothermal cancer therapy, showing effective tumor targeting and prolonged survival in vivo.

Phosphatidylinositol (4,5)-bisphosphate drives the formation of EGFR and EphA2 complexes

This study uses PIE-FCCS to show that PIP2 enhances EGFR and EphA2 multimerization in live cells, revealing a role for anionic lipids in RTK interactions.

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.