The paper identifies marine sulfated glycans that inhibit Borrelia burgdorferi adhesins' binding to heparin/GAGs, with specific inhibitors showing varying potency against different adhesins.

bioRxiv · Sep 23, 2026 · PreprintBiochemistry

Circadian disruption induces sex-specific Alzheimer's pathophysiology and immune cell reprogramming

Carmalena V. Cordi, Naomi G. Falkenberg, Gretchen T. Clark, Noah G. Allen, Joshua Chuah, Russell Ulbrich, Ava A. Herzog, Meghana Lanka, Emily J. Collins, Marvin Bentley, Jonathan S. Dordick, Meaghan S. Jankowski, Jennifer M. Hurley

This study shows circadian disruption causes sex-specific changes in Alzheimer's pathology and immune cell behavior in mice.

bioRxiv · May 5, 2026 · PreprintMolecular Biology

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

Jianfeng Lin, Jian Miao, Katherine G. Schaefer, Charles M. Russell, Robert J. Pyron, Fuming Zhang, Quynh T. Phan, Norma V. Solis, Hong Liu, Masato Tashiro, Jonathan S. Dordick, Robert J. Linhardt, Michael R. Yeaman, Gavin M. King, Francisco N. Barrera, , Scott G. Filler

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

Nature Microbiology · Sep 16, 2024Peer-reviewedMicrobiology