Author

Charnae' Henry-Smith

National Institutes of Health

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Physiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Ada N. OkerekeiD· 1 shared Allison B. HermaniD· 1 shared Dimitrios TsitsipatisiD· 1 shared Douglas R. SealsiD· 1 shared Kevin O. MurrayiD· 1 shared Krystyna Mazan-MamczarziD· 1 shared Matthew J. RossmaniD· 1 shared Myriam GorospeiD· 1 shared

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2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Ada N. OkerekeORCID

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1 paper

Recent·Most cited

Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12

Sophia A. Mahoney, Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae' Henry-Smith, Ada N. Okereke, Rachel B. Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary Stephen Clayton

Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.

Aging Cell · Apr 22, 2026Peer-reviewedPhysiology✦ In-depth digest