Author
University of Colorado Boulder
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
3 papers
Recent·Most cited
Sophia A. Mahoney, Krystyna Mazan-Mamczarz, Dimitrios Tsitsipatis…·Zachary Stephen Clayton
Single-cell aortic transcriptomics and plasma bioassays in aged mice show that intermittent fisetin treatment clears senescent endothelial cells and reverses endothelial dysfunction partially driven by circulating CXCL12.
Ravinandan Venkatasubramanian, Sophia A. Mahoney, David A. Hutton…·Zachary Stephen Clayton
This study shows that cellular senescence contributes to Doxorubicin-induced vascular endothelial dysfunction and that senolytic treatment can prevent this dysfunction.
Ravinandan Venkatasubramanian, Mary Darrah, Sophia A. Mahoney…·Zachary Stephen Clayton
This study shows that doxorubicin chemotherapy induces aortic stiffening via cellular senescence and the senescence-associated secretory phenotype, which can be mitigated by senolytic therapy.