High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the Brain
Md Akkas Ali, Md Hasanul Banna Siam, Donald Vardaman, Chase Bolding, J. Nicholas Brazell, Ashleigh D. Whatley, Christopher A. Risley, Harrison Tidwell, Syed Nakib Hossain, Juhi Samal, Ashley S. Harms, Mallikarjun Patil, Daniel J. Tyrrell
This study identifies age-related neuroinflammatory microglia-T cell circuits in a mouse model of vascular dementia using multi-modal high-dimensional analysis.
bioRxiv · Dec 13, 2025 · PreprintImmunology