Author

J. Nicholas Brazell

HudsonAlpha Institute for Biotechnology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Brianne B. RogersiD· 2 shared J. Nicholas CochraniD· 2 shared Ashleigh D. Whatley· 1 shared Ashley S. HarmsiD· 1 shared Ashlyn G. AndersoniD· 1 shared Belle A. MoyersiD· 1 shared Blynn G. BunneyiD· 1 shared Chase Bolding· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenetics

Brianne B. RogersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects

Rebecca M. Hauser, Henry L. Limbo, J. Nicholas Brazell, Belle A. Moyers, Shelby N. Lauzon, Erin A. Barinaga, S. Quinn Johnston, Brianne B. Rogers, Jared W. Taylor, J. Nicholas Cochran

The paper identifies cis-regulatory elements and genetic variation effects in the MAPT locus using MPRA and CRISPRi in neuronal and HEK293FT cells.

bioRxiv · Mar 25, 2026 · PreprintGenetics

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the Brain

Md Akkas Ali, Md Hasanul Banna Siam, Donald Vardaman, Chase Bolding, J. Nicholas Brazell, Ashleigh D. Whatley, Christopher A. Risley, Harrison Tidwell, Syed Nakib Hossain, Juhi Samal, Ashley S. Harms, Mallikarjun Patil, Daniel J. Tyrrell

This study identifies age-related neuroinflammatory microglia-T cell circuits in a mouse model of vascular dementia using multi-modal high-dimensional analysis.

bioRxiv · Dec 13, 2025 · PreprintImmunology

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer's disease-specific cis regulatory elements.

Ashlyn G. Anderson, Brianne B. Rogers, Jacob M. Loupe, Iván Rodríguez-Nunez, Sydney C. Roberts, Lauren M. White, J. Nicholas Brazell, William E. Bunney, Blynn G. Bunney, Stanley J. Watson, J. Nicholas Cochran, R Myers, Lindsay F. Rizzardi

Cell Genomics · Feb 2, 2023Peer-reviewedGenomics