Ashley S. Harms

This study identifies NF-κB RelA and IRF4 as stage-specific regulators driving -synuclein-induced disease-associated microglia differentiation in Parkinson disease.

This study identifies age-related neuroinflammatory microglia-T cell circuits in a mouse model of vascular dementia using multi-modal high-dimensional analysis.

The paper analyzes T-cell responses and glial pathology in Parkinson's disease substantia nigra using single nucleus RNA sequencing and spatial transcriptomics, revealing CD8+ T-cell characteristics and altered cellular interactions.

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

This study shows that alpha-synuclein overexpression in mice alters gut microbiome composition with age, suggesting a potential link between PD pathology and microbiome dysbiosis.

This study identifies border-associated macrophages (BAMs) as key mediators of alpha-synuclein-induced neuroinflammation in Parkinson's disease.

This study shows that IFNγ from CD4+ T cells drives neuroinflammation and demyelination in a mouse model of MSA.

The paper shows that α-synuclein fibrils activate LRRK2 kinase in monocyte-derived macrophages, linking LRRK2 mutations to pro-inflammatory responses in Parkinson's disease.