Daniel J. Tyrrell

This study shows aging promotes ovarian cancer growth and immunosuppression, which can be mitigated by inhibiting Hedgehog signaling in mice and correlates with immune checkpoint resistance in humans.

This study identifies age-related neuroinflammatory microglia-T cell circuits in a mouse model of vascular dementia using multi-modal high-dimensional analysis.

This study shows that 17β-estradiol improves cerebrovascular endothelial and mitochondrial function in APOEε3 mice but not in APOEε4 mice.

This study shows that diet-induced obesity paradoxically increases SERCA activity in atrial myocytes, contributing to atrial fibrillation through altered Ca2+ dynamics.

CAFE is a web app for analyzing and visualizing high-dimensional spectral flow cytometry data, enabling interactive exploration without coding expertise.

The paper develops a spectral flow cytometry analysis pipeline to identify age-related differences in T cell subsets using high-dimensional data from young and aged mice.

This paper shows that combined Alzheimer's and Parkinson's protein pathologies enhance neuroinflammation and neurodegeneration in a mouse model.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.