Multi-omic profiling of human and mouse dorsal root ganglia enables targeted gene delivery to nociceptors
Lily S He, Parth Bhatia, Shamsuddin A. Bhuiyan, Evangelia Semizoglou, J. Wang, Jia Li, Joohyun Nam, Jay X. J. Luo, Chayse Arnhold, Difei Zhu, Mengyi Xu, Dustin S. Griesemer, Hyo Jeong Yong, Lorna Jayne, Evangeline Gilmer, , NIH PRECISION Human Pain Network
The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.
bioRxiv · Mar 12, 2026 · PreprintNeuroscience