Shamsuddin A. Bhuiyan

The paper shows that somatosensory neuron repertoires in mammals diversify through changes to conserved neuron types, enabling adaptation to different habitats and body forms.

The paper identifies compartment-specific translational programs in sensory neuron axons using spatial translatomics and shows that RNA-binding proteins guide mRNA sorting to establish molecular identities.

The paper creates a canine dorsal root ganglion cell atlas, identifies cell subtypes, and compares them across species to inform pain research.

The paper identifies cis-regulatory elements for targeted gene delivery to nociceptors using multi-omic profiling and develops a sequence-based model to design synthetic enhancers.

The paper identifies OSMR and SST as molecular markers for human dermal sleeping nociceptors, providing new therapeutic targets for neuropathic pain.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper identifies a specific subtype of injured C-fibre nociceptors in neuromas that drive chronic spontaneous neuropathic pain in mice.

The paper uses long-read sequencing to catalog Cacna1e splice variants in rat thalamus and computationally identifies four functionally distinct isoforms.

The paper compares the transcriptome of a human sensory neuron-derived cell line with primary and iPSC-derived sensory neurons to assess its utility as a human model for nociceptive signaling.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

The paper evaluates the functional significance of splice isoforms in human and mouse genes, finding limited experimental evidence for functionally distinct splice isoforms.