Differential sensitivity to LINE 1-induced damage contributes to the expansion of Tet2-deficient HSCs upon chronic inflammatory stress
Anne Stolz, Cheng Xuan, Christelle Freitas, Rabie Chelbi, Hassan Ait-Ougouram, David Fandrei, Mengliang Ye, Elisabeth Nelson, Claire Maillard, Mathieu Bohm, Salomeh El-Choufani, Weiwei Zhang, Audrey Porquet, Kahina Issoulaiene, Christian Muchardt, , Emilie Elvira‐Matelot
The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.
bioRxiv · Jul 21, 2025 · PreprintCell Biology