Emilie Elvira‐Matelot

Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

Differential sensitivity to LINE 1-induced damage contributes to the expansion of Tet2-deficient HSCs upon chronic inflammatory stress

The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.

The Arabidopsis RNA-binding protein SGS3 is recruited to the chromatin remodeler CHR11 to promote siRNA production from protein-coding genes

The paper shows SGS3 recruits CHR11 to select nuclear RNAs for export to the cytosol, promoting siRNA production from protein-coding genes under stress.

CXCL8 secreted by immature granulocytes inhibits wildtype hematopoiesis in chronic myelomonocytic leukemia

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.