Christian Muchardt

This study shows that HP1 interacts with the RNA exosome, affecting RNA degradation and transcriptional programs in liver cells, with implications for cancer biology.

The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.

The paper identifies reduced CBX5 expression and impaired Integrator activity in MS patients, linking them to transcriptomic alterations and disease progression.

The paper identifies Alu elements as dynamic boundaries in regulatory elements, influencing histone modifications and DNA methylation patterns across tissues and age.

This paper investigates how influenza A virus RNA polymerase (FluPol) interacts with host chromatin during infection, showing it targets regulatory elements of immune response genes and interferes with transcription processes.

The paper shows that RNA accumulation, driven by reduced RNA turnover and oxidative stress, contributes to the inflammatory state of senescent cells.

The paper identifies HP1γ's RNA binding activity in transcribed genes and shows it enhances splicing fidelity by tethering pre-mRNA to chromatin through intronic repeats.

The paper investigates how DNA methylation affects alternative splicing in tumors, finding that meDNA influences splicing patterns and is linked to cancer progression.

The paper shows that dieldrin activates endogenous retroviruses in MS by triggering multiple signaling pathways and altering transcriptional regulation.