Mathieu Bohm

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

This paper presents a protocol for inducing innate immune memory in mice using repeated β-glucan injections and assesses it through enhanced bone marrow hematopoiesis and GMP production.

The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.

This study shows that combining DNA hypomethylating agents with H3K9me2 inhibitors reactivates immune pathways and eliminates malignant stem cells in CMML by targeting heterochromatin disorganization.