Author

Hassan Ait-Ougouram

Inserm

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Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Audrey Porquet· 2 shared Elina ZuevaiD· 2 shared Emilie Elvira‐MatelotiD· 2 shared Françoise PorteuiD· 2 shared Mathieu BohmiD· 2 shared Mengliang YeiD· 2 shared Rabie ChelbiiD· 2 shared Anne StolziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCell Biology

Audrey Porquet

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 31, 2026

Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress

Audrey Porquet, Mathieu Bohm, Hassan Ait-Ougouram…·Françoise Porteu

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

DOI 10.64898/2026.08.28.747860

mouseChIP-seq

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Cell BiologybioRxivPreprintJul 21, 2025

Differential sensitivity to LINE 1-induced damage contributes to the expansion of Tet2-deficient HSCs upon chronic inflammatory stress

Anne Stolz, Cheng Xuan, Christelle Freitas…·Emilie Elvira‐Matelot

The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.

1 citation

mouseDNA methylation

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