Cell BiologybioRxivPreprint
Differential sensitivity to LINE 1-induced damage contributes to the expansion of Tet2-deficient HSCs upon chronic inflammatory stress
Anne Stolz, Cheng Xuan, Christelle Freitas…·Emilie Elvira‐Matelot
The paper shows that Tet2-deficient HSCs are resistant to LPS-induced L1 derepression and genomic instability, which contributes to their clonal expansion under chronic inflammation.
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