VARS1 fuels prostate cancer evolution via codon-selective translational rewiring
Qinju He, Rongrong He, Yingying Li, Miaomiao Xu, Shuchao Ren, Cheng Zou, Zhenyu Li, Wenchao Li, Yuanzhen Zhang, Lanxin Hu, Bin Xu, Baobing Zhao, Zhipeng Zhou, Dingxiao Zhang
This study identifies VARS1 as a driver of prostate cancer progression by altering codon usage in translation, showing that targeting VARS1 can suppress tumor growth through dietary valine restriction or inhibitors.
bioRxiv · Dec 12, 2025 · PreprintCancer Biology