The role of intrinsically disordered domains in regulating G protein coupled receptor signaling
Jun Zhi Xu, Ruoyi Qiu, Alexander M. Garces, Harald Hübner, Xinyu Xu, Chengyu Hao, Dorothée Weikert, Peter Gmeiner, Michael T. Lerch, Brian K. Kobilka
This study uses single-molecule imaging to show how agonist-specific dynamics in structured and disordered regions of the 2AAR regulate signaling and function.
Journal of the American Chemical Society · Dec 27, 2025Peer-reviewedBiophysics